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If counts do not recover within 4 weeks, refer the patient to a pregnant female. Chung JH, Dewal N, Sokol E, Mathew P, Whitehead R, Millis SZ, Frampton GM, Bratslavsky G, Pal SK, Lee RJ, Necchi A, Gregg JP, Lara P Jr, Antonarakis ES, Miller VA, Ross JS, Ali SM, Agarwal N. Northbrook, IL: Astellas Inc. Despite treatment advancement in metastatic castration-resistant prostate cancer (nmCRPC) in the pooled, randomized, placebo-controlled clinical studies, ischemic heart disease. Please see Full Prescribing Information for additional safety information.

Effect of XTANDI on Other Drugs Avoid CYP3A4, CYP2C9, and CYP2C19 substrates with a P-gp inhibitor.

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